What is new in HIES? Recent insights from the interface of primary immune deficiency and atopy. Issue 6 (December 2018)

• Record Type: Journal Article
• Authors: Ponsford, Mark J.; Rae, William; Klocperk, Adam
• Is Part Of: Current opinion in allergy and clinical immunology. Volume 18:Issue 6(2018:Dec.)
• Publication Date: 2018-12
• Subjects: genome-wide association study -- next-generation sequencing -- primary atopic disease -- primary immunodeficiency; Allergy -- Periodicals; Clinical immunology -- Periodicals; Hypersensitivity; Immunity; Immune System Diseases; Allergy and Immunology; 616.079
• DOI: 10.1097/ACI.0000000000000481
• Languages: English
• ISSNs: 1528-4050

Abstract

Abstract : Purpose of review: Understanding the pathophysiology of monogenic primary immunodeficiency (PID) with atopic presentation has pivotal implications for intervention strategies and potentially wider polygenic atopic-related traits. This review will discuss advances in gene discovery arising from monogenic defects at the interface between PID and atopy, notably the hyper-IgE syndromes. Recent findings: Key molecular pathways underlying development of primary atopic diseases have recently been proposed. We test this classification through reviewing novel genes reported in the last 2 years and compare insights from pathway-analysis of genome-wide association studies (GWAS) of atopic-related traits. Growing access to next-generation sequencing (NGS) has resulted in a surge in gene discovery, highlighting the utility and some pitfalls of this approach in clinical practice. The variability of presenting phenotypes reveals important gene-dosage effects. This has important implications for therapeutic strategies such as protein stabilization and modulators of JAK-STAT or TH 2-cytokine signalling. We also consider the therapeutic implications raised by CARD11 deficiency, and wider applications of NGS including polygenic risk score in atopy. Summary: Disorders presenting at the interface between PID and allergy are often difficult to diagnose, with serious consequences if missed. Application of NGS has already provided critical insights to pathways enabling targeted therapeutic interventions, and potential wider translation to polygenic disorders. Abstract : Supplemental Digital Content is available in the text