Analysis of heterogeneous cardiac pacemaker tissue models and traveling wave dynamics. (14th December 2018)

• Record Type: Journal Article
• Authors: Ly, Cheng; Weinberg, Seth H.
• Is Part Of: Journal of theoretical biology. Volume 459(2018)
• Page Start: 18
• Page End: 35
• Publication Date: 2018-12-14
• Subjects: Sinoatrial-node -- Traveling waves -- Heterogeneous pacemaker cells -- Phase reduction -- Phase oscillators; Biology -- Periodicals; Biological Science Disciplines -- Periodicals; Biology -- Periodicals; Biologie -- Périodiques; Theoretische biologie; Biology; Periodicals; 571.05
• DOI: 10.1016/j.jtbi.2018.09.023
• Languages: English
• ISSNs: 0022-5193

Abstract

Highlights: Adapted a real pacemaker model that has calcium handling and perturbations to the funny current to model other cell types. Analyzed spatio-temporal dynamics of tissue and did not find central wave generation despite biophysical realism. Found peripheral wave generation that is consistent with experiments that removed the atrium. Reduced model captured frequency, stability, and transient times of traveling waves; transients showed center-to-peripheral. Thus, central wave generation in these realistic models must occur transiently or require atrium and/or fibrous tissue. Abstract: The sinoatrial-node (SAN) is a complex heterogeneous tissue that generates a stable rhythm in healthy hearts, yet a general mechanistic explanation for when and how this tissue remains stable is lacking. Although computational and theoretical analyses could elucidate these phenomena, such methods have rarely been used in realistic (large-dimensional) gap-junction coupled heterogeneous pacemaker tissue models. In this study, we adapt a recent model of pacemaker cells (Severi et al., 2012), incorporating biophysical representations of ion channel and intracellular calcium dynamics, to capture physiological features of a heterogeneous population of pacemaker cells, in particular "center" and "peripheral" cells with distinct intrinsic frequencies and action potential morphology. Large-scale simulations of the SAN tissue, represented by a heterogeneous tissue structure of pacemaker cells, exhibit a rich repertoire of behaviors, including complete synchrony, traveling waves of activity originating from periphery to center, and transient traveling waves originating from the center. We use phase reduction methods that do not require fully simulating the large-scale model to capture these observations. Moreover, the phase reduced models accurately predict key properties of the tissue electrical dynamics, including wave frequencies when synchronization occurs, and wave propagation direction in a variety of tissue models. With the reduced phase models, we analyze the relationship between cell distributions and coupling strengths and the resulting transient dynamics. Further, the reduced phase model predicts parameter regimes of irregular electrical dynamics. Thus, we demonstrate that phase reduced oscillator models applied to realistic pacemaker tissue is a useful tool for investigating the spatial-temporal dynamics of cardiac pacemaker activity.