Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches. Issue 5 (12th September 2018)

• Record Type: Journal Article
• Authors: Guo, Yingying; Chu, Xiaoyan; Parrott, Neil J.; Brouwer, Kim L.R.; Hsu, Vicky; Nagar, Swati; Matsson, Pär; Sharma, Pradeep; Snoeys, Jan; Sugiyama, Yuichi; Tatosian, Daniel; Unadkat, Jashvant D.; Huang, Shiew‐Mei; Galetin, Aleksandra
• Other Names: Hoeben Eef investigator.; Chen Dapeng investigator.; Hartmann Georgy investigator.; Menzel Karsten investigator.
• Is Part Of: Clinical pharmacology & therapeutics. Volume 104:Issue 5(2018)
• Page Start: 865
• Page End: 889
• Publication Date: 2018-09-12
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1002/cpt.1183
• Languages: English
• ISSNs: 0009-9236

Abstract

Abstract : This white paper examines recent progress, applications, and challenges in predicting unbound and total tissue and intra/subcellular drug concentrations using in vitro and preclinical models, imaging techniques, and physiologically based pharmacokinetic (PBPK) modeling. Published examples, regulatory submissions, and case studies illustrate the application of different types of data in drug development to support modeling and decision making for compounds with transporter‐mediated disposition, and likely disconnects between tissue and systemic drug exposure. The goals of this article are to illustrate current best practices and outline practical strategies for selecting appropriate in vitro and in vivo experimental methods to estimate or predict tissue and plasma concentrations, and to use these data in the application of PBPK modeling for human pharmacokinetic (PK), efficacy, and safety assessment in drug development.