Bioactive mono/bis (carboxyamide) based Co (II), Ni (II) and Cu (II) complexes: Synthesis, Characterization, DNA binding and Anticancer Potentials. (19th November 2018)

• Record Type: Journal Article
• Authors: Dhivya, Raman; Kathiresan, Sellamuthu; Vigneshwar, Murugesan; Ranjani, Jothi; Rajendhran, Jeyaprakash; Bhuvanesh, Nattamai S.P.; Annaraj, Jamespandi
• Is Part Of: Applied organometallic chemistry. Volume 33:Number 1(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-11-19
• Subjects: antitumor activity -- apoptosis -- DNA binding -- hepatotoxicity -- MTT assay; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.4660
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : Bioactive carboxyamide ligated Cu II (1 ), Co II (2 ) and Ni II (3 ) complexes have been synthesized and characterized using various physico‐chemical techniques. In particular, the occurred slightly distorted square planar geometry in complex1 was confirmed by single X‐ray crystal structure. Their (1, 2 and3 ) potential interactions with herring sperm DNA (HS‐DNA) have been investigated using spectral and electrochemical techniques. All these studies suggested that the complex1 could partially penetrated in the sugar phosphate backbone and stacked in between the DNA base pairs, while the other complexes2 &3 could bound only on the grooves of HS‐DNA due to their bi‐ligated architecture around the metal centre. The potent cytotoxicity of L and its complexes1–3 was also evaluated against AGS human gastric cancer cells. Hoechst 33342/PI double staining images revealed that the complexes significantly induced cell death through apoptosis. In vivo administration of complex1 remarkably inhibits the tumor growth in male Swiss albino mice, moreover it did not show any hepatotoxicity in mice. All these observed results suggested that these complexes may utilized as good conventional therapeutic agents in the near feature after a series of biological assessments. Abstract : Copper complex with slightly distorted square planar geometry, potent cytotoxicity in AGS human gastric cancer cells and in vivo administration of complex1 remarkably inhibits the tumor growth in male Swiss albino mice, moreover it did not show any hepatotoxicity in mice.