Med1 deficiency alters the somatic hypermutation spectrum in murine B cells. Issue 4 (14th February 2018)
- Record Type:
- Journal Article
- Title:
- Med1 deficiency alters the somatic hypermutation spectrum in murine B cells. Issue 4 (14th February 2018)
- Main Title:
- Med1 deficiency alters the somatic hypermutation spectrum in murine B cells
- Authors:
- Gaudot, Léa
Thomas‐Claudepierre, Anne‐Sophie
Robert, Isabelle
Schiavo, Ebe
Heyer, Vincent
Reina‐San‐Martin, Bernardo - Abstract:
- Abstract : The Mediator complex is known to orchestrate transcription. Here we show that B cell conditional deficient mice for the Med1 subunit display robust somatic hypermutation. Nevertheless, the mutation frequency at A residues is decreased and the expected A/T ratio is abolished, implicating Mediator in the second phase of somatic hypermutation.
- Is Part Of:
- European journal of immunology. Volume 48:Issue 4(2018)
- Journal:
- European journal of immunology
- Issue:
- Volume 48:Issue 4(2018)
- Issue Display:
- Volume 48, Issue 4 (2018)
- Year:
- 2018
- Volume:
- 48
- Issue:
- 4
- Issue Sort Value:
- 2018-0048-0004-0000
- Page Start:
- 720
- Page End:
- 723
- Publication Date:
- 2018-02-14
- Subjects:
- Activation‐induced cytidine deaminase -- Antibody diversification -- B lymphocyte -- Mediator -- Somatic hypermutation
Immunology -- Periodicals
616.079 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/eji.201747258 ↗
- Languages:
- English
- ISSNs:
- 0014-2980
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3829.730100
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 11303.xml