Chemical constituents and antileukemic activity of Eugenia dysenterica. Issue 16 (18th August 2017)

• Record Type: Journal Article
• Authors: Vitek, Renan; de Novais, Leice M. R.; Torquato, Heron F. V.; Paredes-Gamero, Edgar J.; de Carvalho, Mário G.; de Sousa, Paulo T.; Jacinto, Marcos J.; da Silva, Virgínia C.
• Is Part Of: Natural product research. Volume 31:Issue 16(2017)
• Page Start: 1930
• Page End: 1934
• Publication Date: 2017-08-18
• Subjects: Eugenia dysenterica -- galloyl flavonol -- cell death -- cell cycle arrest -- cell differentiation -- leukemia; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1261343
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The study about Eugenia dysenterica led to the isolation of 3 - acetyl - urs - 12-en-28 - oic (1 ), 3-acetyl-olean-12-en-28-oic acid (2 ) and isoquercetin (3 ) from the stem barks, and of 3- O -β-glucopyranosyl-β-sitosterol (4 ), methyl 3-hydroxy-4-methoxybenzoate (5 ), methyl 4-hydroxyphenyl propionate (6 ), E -methyl-4-hydroxycinnamate (7 ), quercetin-3- O -(6ꞌꞌ- O -galloyl)-β-d -glucopyranoside (8 ) and quercetin-3- O -β-d -galactopyranoside (9 ) from the leaves. The structures1 –9 were set through the analysis of their NMR spectroscopic data. Compounds2, 3 and5 –8 were reported for the first time in the Eugenia genus. Compound8 reduced cell viability and presented IC50 values 40.3 and 36.7 μM, for the CCRF-CEM and the Kasumi-1 cells, respectively. Abstract :