Palladium-catalyzed decarboxylative C3-acylation of benzofurans and benzothiophenes with α-oxocarboxylic acids via direct sp2 C–H bond activation. Issue 8 (25th February 2015)

• Record Type: Journal Article
• Authors: Gong, Wei-Jie; Liu, De-Xian; Li, Fei-Long; Gao, Jun; Li, Hong-Xi; Lang, Jian-Ping
• Is Part Of: Tetrahedron. Volume 71:Issue 8(2015)
• Page Start: 1269
• Page End: 1275
• Publication Date: 2015-02-25
• Subjects: Decarboxylation -- Palladium(II) -- Benzofuran -- Benzothiophene -- Acylation -- α-Oxocarboxylic acids; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2014.12.095
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: An efficient approach to decarboxylative C3-acylation of benzothiophenes or benzofurans with α-oxocarboxylic acids via palladium-catalyzed C–H bond activation was developed. This method was compatible with a variety of functional groups and provided an attractive route to 3-acylbenzothiophenes and 3-acylbenzofurans in good to high yields. Graphical abstract: