Ambient particulate air pollution and circulating antioxidant enzymes: A repeated-measure study in healthy adults in Beijing, China. (January 2016)

• Record Type: Journal Article
• Authors: Wu, Shaowei; Wang, Bin; Yang, Di; Wei, Hongying; Li, Hongyu; Pan, Lu; Huang, Jing; Wang, Xin; Qin, Yu; Zheng, Chanjuan; Shima, Masayuki; Deng, Furong; Guo, Xinbiao
• Is Part Of: Environmental pollution. Volume 208:Part A(2016)
• Page Start: 16
• Page End: 24
• Publication Date: 2016-01
• Subjects: Air pollution -- Antioxidant enzyme -- Chemical constituent -- Particulate matter; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2015.06.002
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: The association of systemic antioxidant activity with ambient air pollution has been unclear. A panel of 40 healthy college students underwent repeated blood collection for 12 occasions under three exposure scenarios before and after relocating from a suburban area to an urban area in Beijing, China in 2010–2011. We measured various air pollutants including fine particles (PM2.5 ) and determined circulating levels of antioxidant enzymes extracellular superoxide dismutase (EC-SOD) and glutathione peroxidase 1 (GPX1) in the laboratory. An interquartile range increase of 63.4 μg/m 3 at 3-d PM2.5 moving average was associated with a 6.3% (95% CI: 0.6, 12.4) increase in EC-SOD and a 5.5% (95% CI: 1.3, 9.8) increase in GPX1. Several PM2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1. Our results support activation of circulating antioxidant enzymes following exposure to particulate air pollution. Highlights: The association of systemic antioxidant activity with air pollution has been unclear. We investigated the association in healthy adults with repeated measurements. PM2.5 was strongly associated with circulating levels of antioxidant enzymes. Nitrate, chloride, iron and strontium contributed to the positive association. Exposure to particulate air pollution may activate systemic antioxidant activity. Abstract : Our study suggests that exposure to fine particles may enhance systemic antioxidant activities in healthy adults in the context of suburban and urban air pollution.