Generalised muscle weakness after bladder wall injection of Abobotulinum Toxin A: experience of a woman with tetraplegia who required increased caregiver support: importance of doctor–patient communication: duty of candour for spinal cord physician and responsibilities of a patient. (December 2018)

• Record Type: Journal Article
• Authors: Vaidyanathan, Subramanian; Foster, Tracey; Soni, Bakul
• Is Part Of: Spinal cord series and cases. Volume 4(2018)
• Page Start: 1
• Page End: 6
• Publication Date: 2018-12
• Subjects: Spinal cord -- Wound and injuries -- Periodicals; Spinal cord -- Diseases -- Periodicals; 617.482044
• DOI: 10.1038/s41394-018-0128-x
• Languages: English
• ISSNs: 2058-6124

Abstract

Abstract Introduction Generalised muscle weakness can occur after bladder wall injection of Abobotulinum toxin and the patient may require additional caregiver support. Case presentation A woman with C-8 AIS A tetraplegia received bladder wall injection of Abobotulinum toxin A 1000 units for detrusor over-activity. After 2.5 weeks, she developed weakness of arms; could not lift herself for pressure relief; could not transfer using sliding board; she regained the original muscle strength in 6 weeks. After 13 months, Abobotulinum toxin A 1000 units were injected into detrusor. Ten days after the second Abobotulinum toxin A injection, she developed generalised muscle weakness. She had not regained full function in her arms and hands 8 months later. Prior to bladder wall injection of Abobotulinum toxin A, this patient was not aware that she could develop muscle weakness albeit very rarely. Therefore, the patient made no association of the muscle weakness, which occurred after the first injection, to Abobotulinum toxin A. For this reason, she did not inform the clinicians that she developed weakness of upper limbs following Abobotulinum toxin A injection. As she was not informed of this side effect before the second bladder wall injection of Abobotulinum toxin A, she consented to undergo the repeat procedure and developed generalised muscle weakness. Discussion Patients should inform doctors the adverse effects of medical therapy so that future treatment is amended to ensure patient safety. Professional duty of candour states that doctors should discuss risks which occur often, those that are serious even if very unlikely, and those that are important to the patient.