"Turn‐On" Activatable AIE Dots for Tumor Hypoxia Imaging. Issue 41 (27th June 2019)

• Record Type: Journal Article
• Authors: Xue, Tianhao; Jia, Xiangqian; Wang, Jilei; Xiang, Jingyuan; Wang, Wei; Du, Juanjuan; He, Yaning
• Is Part Of: Chemistry. Volume 25:Issue 41(2019)
• Page Start: 9634
• Page End: 9638
• Publication Date: 2019-06-27
• Subjects: AIE -- azobenzene -- fluorescence probe -- hypoxia -- self-assembly; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201902296
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A hypoxia‐responsive fluorescence probe of amphiphilic PEGylated azobenzene caged tetraphenylethene (TPE) for tumor cell imaging is reported; it possesses excellent solubility in aqueous medium due to the easy formation of micelles by self‐assembly. The fluorescence resonance energy transfer (FRET) process ensures that the fluorescence of the azobenene caged AIE fluorogen is quenched efficiently. When cultured with tumor cells, the azo‐bond is reduced under hypoxia conditions and the fluorescence of AIE fluorogen recovers dramatically. Besides using UV light, NIR light can also be used as the excited light resource to generate the fluorescence due to the two‐photon fluorescence imaging process. Abstract : A hypoxia‐responsive fluorescence probe of amphiphilic PEGylated azobenzene caged tetraphenylethene for tumor cell imaging is reported (see scheme). Besides using UV light, NIR light can also be used as the excited light resource to generate the fluorescence due to the two‐photon fluorescence imaging process.