Tuning Channel Architecture of Interdigitated Organic Electrochemical Transistors for Recording the Action Potentials of Electrogenic Cells. (27th May 2019)

• Record Type: Journal Article
• Authors: Liang, Yuanying; Brings, Fabian; Maybeck, Vanessa; Ingebrandt, Sven; Wolfrum, Bernhard; Pich, Andrij; Offenhäusser, Andreas; Mayer, Dirk
• Is Part Of: Advanced functional materials. Volume 29:Number 29(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-05-27
• Subjects: cardiac action potentials -- channel resistance -- interdigitated electrode arrays -- organic electrochemical transistors -- source–drain series resistance; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201902085
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Organic electrochemical transistors (OECTs) have emerged as versatile electrophysiological sensors due to their high transconductance, biocompatibility, and transparent channel material. High maximum transconductances are demonstrated facilitating the extracellular recording of signals from electrogenic cells. However, this requires large channel dimensions and thick polymer films. These large channel dimensions lead to low transistor densities. Here, interdigitated OECTs (iOECTs) are introduced, which feature high transconductances at small device areas. A superior device performance is achieved by systematically optimizing the electrode layout regarding channel length, number of electrode fingers and electrode width. Interestingly, the maximum transconductance ( g max ) does not straightforwardly scale with the channel width‐to‐length ratio, which is different from planar OECTs. This deviation is caused by the dominating influence of the source–drain series resistance R sd for short channel devices. Of note, there is a critical channel length (15 µm) above which the channel resistance R ch becomes dominant and the device characteristics converge toward those of planar OECTs. Design rules for engineering the performance of iOECTs are proposed and tested by recording action potentials of cardiomyocyte‐like HL‐1 cells with high signal‐to‐noise ratios. These results demonstrate that interdigitated OECTs meet two requirements of bioelectronic applications, namely, high device performance and small channel dimensions. Abstract : Interdigitated organic electrochemical transistors (iOECTs) exhibit tunable high transconductance, which have no straightforward relationship with the channel width‐to‐length ratio due to a dominating effect of source–drain series resistances at short channel length ( L ch ). Above a critical L ch, the performance of iOECTs converges toward that of planar OECTs. The high transconductance allows iOECTs to monitor the action potentials of individual cardiac‐like cells with high signal‐to‐noise ratios.