Organosilica Nanoparticles for Gemcitabine Monophosphate Delivery in Cancer Cells. Issue 7 (30th April 2019)

• Record Type: Journal Article
• Authors: Daurat, Morgane; Rahmani, Saher; Bouchal, Roza; Akrout, Alia; Budimir, Jelena; Nguyen, Christophe; Charnay, Clarence; Guari, Yannick; Richeter, Sébastien; Raehm, Laurence; Bettache, Nadir; Gary‐Bobo, Magali; Durand, Jean‐Olivier; Hesemann, Peter
• Is Part Of: ChemNanoMat. Volume 5:Issue 7(2019)
• Page Start: 888
• Page End: 896
• Publication Date: 2019-04-30
• Subjects: gemcitabine monophosphate -- organosilica nanoparticles -- drug delivery -- cancer -- ionosilica; Nanochemistry -- Periodicals; Nanostructured materials -- Periodicals; Nanochemistry; Nanostructured materials; Periodicals; 541.2
• DOI: 10.1002/cnma.201900202
• Languages: English
• ISSNs: 2199-692X

Abstract

Abstract: Organosilica nanoparticles hold great promise for nanomedicine applications. These nanoparticles are synthesized from polytrialkoxysilylated precursors without any silica source. In this work we present two kinds of organosilica nanoparticles with either amine or ammonium walls constituting their structure. Both types of nanoparticles are very efficient for gemcitabine monophosphate delivery, a small hydrophilic anticancer drug whose encapsulation is still a challenge. The nanoparticles are endocytosed by MCF‐7 breast cancer cells as monitored by confocal microscopy. They are efficient and lead to 60% cancer cell death. Abstract : Free delivery : Two different types of organosilica nanoparticles have been created with either tertiary amines or ammonium walls. These nanoparticles were very efficient for gemcitabine monophosphate delivery in breast cancer cells after endocytosis.