Framework Nucleic Acids: A Paradigm Shift in Transdermal Drug Delivery. (October 2019)

• Record Type: Journal Article
• Authors: Wiraja, Christian; Yeo, David C.; Xu, Chenjie
• Is Part Of: SLAS technology. Volume 24:Number 5(2019)
• Page Start: 531
• Page End: 532
• Publication Date: 2019-10
• Subjects: framework nucleic acid -- nanocarrier -- transdermal delivery -- self-application; Medical laboratory technology -- Periodicals; Laboratories -- Equipment and supplies -- Periodicals; Diagnosis, Laboratory -- Periodicals; 616.075
• DOI: 10.1177/2472630319848679
• Languages: English
• ISSNs: 2472-6303

Abstract

Transdermal drug delivery (TDD) provides a direct drug administration route bypassing gastrointestinal and liver metabolism. Until now, topical nanocarriers responsible for efficient TDD are predominantly polymeric or lipid based. The size-dependent skin penetration ability of framework nucleic acids (FNAs) has recently been reported, along with their efficacy in delivering doxorubicin for skin melanoma therapy. This commentary is to highlight the paradigm shift of nucleic acid delivery from being a cargo moiety to serving as a drug carrier instead. Further development directions to maximize the potential of FNAs for TDD are also discussed.