Recent Strategies in Resveratrol Delivery Systems. Issue 7 (10th July 2019)

• Record Type: Journal Article
• Authors: Machado, Noelia D.; Fernández, Mariana A.; Díaz, David Díaz
• Is Part Of: ChemPlusChem. Volume 84:Issue 7(2019)
• Page Start: 951
• Page End: 973
• Publication Date: 2019-07-10
• Subjects: drug delivery systems -- encapsulation -- nutrition -- pharmaceutics -- resveratrol; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cplu.201900267
• Languages: English
• ISSNs: 2192-6506

Abstract

Abstract: Resveratrol, a natural polyphenolic stilbenoid widely found in grapes and wines, displays beneficial properties such as cardio‐protective, antioxidant and anti‐inflammatory activities. Trans‐resveratrol (RSV) is the most bioactive and more abundant stereoisomer found in nature. Despite the positive properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chemical instability. During the last years, an increasing number of strategies such as nano and micro encapsulation have been developed in order to overcome these limitations and enhance the use of RSV in nutritional and pharmaceutical applications. This Review summarizes the advances and main properties of several RSV carriers and delivery systems reported during the last 5 years. Abstract : Overcoming limitations : This Review summarizes the advances and main features of several resveratrol (RSV) carriers, designed to overcome some of its adverse properties, as low solubility, low oral bioavailability, and chemical instability. Formulations of different natures have been developed that have allowed more potential applications for RSV in food and pharmaceutical sciences.