Hydrophilic Porous Poly(l‐Lactic Acid) Nanomembranes: Self‐Assembly, and Anti‐Biofouling and Anti‐Thrombosis Effects. Issue 7 (23rd July 2019)

• Record Type: Journal Article
• Authors: Deng, Xiulong; Zhang, Mengbi; Tan, Lishan; Zeng, Tao; Lai, Xuandi; Geng, Xinran; Huang, Caili; Li, Aiqing; Pan, Yanchao; Hu, Jianqiang
• Is Part Of: ChemPlusChem. Volume 84:Issue 7(2019)
• Page Start: 989
• Page End: 998
• Publication Date: 2019-07-23
• Subjects: anti-biofouling -- anti-thrombosis -- membranes -- polyethylene glycol -- self-assembly; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cplu.201900256
• Languages: English
• ISSNs: 2192-6506

Abstract

Abstract: Hydrophilic PEGylated porous self‐assembled nanomembranes (PSANMs) with average thickness and pore diameter of ca . 10 and 20–24 nm were successfully prepared by an emulsification‐induced programmable self‐assembly strategy. The hydrophilicity, anti‐biofouling, and anti‐thrombosis properties of PEGylated PSANMs were largely improved in comparison with the nonfunctionalized PSANMs, which could transform into hydrophilic (PEGylated PSANMs, minimum water contact angle: 38.8°) from hydrophobic units (PSANMs, maximum water contact angle: 137.5°) with increasing PEG density and length. The total protein adsorption of PEGylated PSANMs was about six times lower than that of the PSANMs, while the thrombosis of the PEGylated PSANMs (maximum R‐time: 5.37 min) was also greatly relieved in comparison with the PSANMs (minimum R‐time: 2.93 min). Such PEG‐modified PSANMs may have applications in drug delivery and tissue and organ repair in vivo . Abstract : Porous self‐assembled nanomembranes (PSANMs) with nanoscale thickness (ca. 10 nm) and pore diameter (24–27 nm) were fabricated through an emulsification‐induced self‐assembly strategy employing carboxyl‐terminal poly(l ‐lactic acid) (Gn−(COOH) x ). These hydrophobic PSANMs caused high protein absorption, which was effectively alleviated by surface PEGylation. The hydrophilic PEGylated PSANMs exhibited excellent anti‐biofouling and anti‐thrombosis properties.