Protective effects of a novel water-soluble biphenyl compound WLP-S-14 against acute-on-chronic liver failure in rats. Issue 9 (2nd September 2019)

• Record Type: Journal Article
• Authors: Wang, Shao-Yuan; Li, Mei; Miao, Lu-Yang; Wu, Song; Tong, Yuan-Feng; Zhang, Wen-Xuan; Zhang, Yu-Yang; Sun, Hua
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 9(2019)
• Page Start: 928
• Page End: 938
• Publication Date: 2019-09-02
• Subjects: WLP-S-14 -- bicyclol -- biphenyl -- acute-on-chronic liver failure; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1585822
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: This study investigated the therapeutic effects of a water-soluble biphenyl compound, WLP-S-14, in acute-on-chronic liver failure (ACLF). Wistar rats were injected intraperitoneally with porcine serum twice a week for 8 weeks prior to administration of 600 mg/kg D-galactosamine and 50 μg/kg lipopolysaccharide to induce ACLF. Study groups were treated intravenously with saline or with 100 or 200 mg/kg WLP-S-14. WLP-S-14 ameliorated ACLF with significant reductions in the mortality rate and transaminase levels, indicating improved liver function. The mechanism underlying these effects may involve decreased levels of tumor necrosis factor-α and interleukin-6, with associated inhibition of apoptotic pathways. Graphical Abstract: