DNA methylation modifications induced by hexavalent chromium. (3rd July 2019)

• Record Type: Journal Article
• Authors: Guo, Xinnian; Feng, Lingfang; Lemos, Bernardo; Lou, Jianlin
• Is Part Of: Journal of environmental science and health. Volume 37:Number 3(2019)
• Page Start: 133
• Page End: 145
• Publication Date: 2019-07-03
• Subjects: hexavalent chromium -- DNA methylation -- hypermethylation -- hypomethylation; Carcinogenesis -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmentally induced diseases -- Periodicals; Environmental Health -- periodicals; Carcinogens, Environmental -- periodicals; Hazardous Substances -- periodicals; 616.994071
• DOI: 10.1080/10590501.2019.1592640
• Languages: English
• ISSNs: 1059-0501

Abstract

Abstract: Hexavalent chromium [Cr (VI)] contributes a significant health risk and causes a number of chronic diseases and cancers. While the genotoxic and carcinogenic effects of hexavalent chromium exposure are explicit and better-characterized, the exact mechanism underlying the carcinogenic process of Cr (VI) is still a matter of debate. In recent years, studies have shown that epigenetic modifications, especially DNA methylation, may play a significant role in Cr (VI)-induced carcinogenesis. The aim of this review is to summarize our understanding regarding the effects of Cr (VI) on global and gene-specific DNA methylation.