Detect Key Gene Information in Classification of Microarray Data. (10th June 2008)

• Record Type: Journal Article
• Authors: Liu Liu, Yihui Yihui
• Other Names: Chung Chung P.-C. P.-C. Academic Editor.
• Is Part Of: EURASIP journal on advances in signal processing. Volume 2008(2008)
• Publication Date: 2008-06-10
• Subjects: Signal processing -- Periodicals; Traitement du signal; Signal processing; Periodicals; 621.3822
• DOI: 10.1155/2008/612397
• Languages: English
• ISSNs: 1687-6172

Abstract

Abstract : We detect key information of high-dimensional microarray profiles based on wavelet analysis and genetic algorithm. Firstly, wavelet transform is employed to extract approximation coefficients at 2nd level, which remove noise and reduce dimensionality. Genetic algorithm (GA) is performed to select the optimized features. Experiments are performed on four datasets, and experimental results prove that approximation coefficients are efficient way to characterize the microarray data. Furthermore, in order to detect the key genes in the classification of cancer tissue, we reconstruct the approximation part of gene profiles based on orthogonal approximation coefficients. The significant genes are selected based on reconstructed approximation information using genetic algorithm. Experiments prove that good performance of classification is achieved based on the selected key genes.