Shape‐memory bioresorbable terpolymer composite with antirestenotic drug. Issue 17 (14th January 2015)

• Record Type: Journal Article
• Authors: Jaworska, Joanna; Jelonek, Katarzyna; Sobota, Michal; Kasperczyk, Janusz; Dobrzynski, Piotr; Musial‐Kulik, Monika; Smola‐Dmochowska, Anna; Janeczek, Henryk; Jarzabek, Bozena
• Is Part Of: Journal of applied polymer science. Volume 132:Issue 17(2015:Sep. 05)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-01-14
• Subjects: biodegradable -- biomedical applications -- drug delivery systems; Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.41902
• Languages: English
• ISSNs: 0021-8995

Abstract

ABSTRACT: Shape‐memory polymers (SMPs) that combine shape‐memory, biodegradability, and controlled drug release properties are very promising for medical and pharmaceutical application. Moreover, incorporation of antirestenotic drug into SMP biodegradable stent seems to be an interesting solution because of possibility to combine the mechanical support that provides stent and also drug elution. The aim of our study was to analyze the effect of incorporation of sirolimus into poly(l ‐lactide‐ co ‐glycolide‐ co ‐trimethylene carbonate) on physicochemical and mechanical properties, degradation, and shape‐memory effect of the terpolymer. For this purpose, sirolimus was incorporated into the terpolymer by injection molding method. It has been demonstrated that drug‐free terpolymer after injection molding characterized insignificant changes in terpolymer composition. Degradation of materials during processing was not observed. Incorporation of drug molecules did not change shape‐memory properties of terpolymer. 1 H‐ and 13 C‐NMR spectra of poly(lactide‐ co ‐glycolide‐ co ‐trimethylene carbonate) confirmed that changes during degradation were similar for terpolymer and terpolymer with sirolimus. Sustained and regular release of sirolimus was observed. The developed material presents potential for biomedical and pharmaceutical applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2015, 132, 41902. Abstract :