The role of neutrophils in the pathogenesis of Crohn's disease. (7th November 2018)

• Record Type: Journal Article
• Authors: Segal, Anthony W.
• Other Names: Roos Dirk guestEditor.
• Is Part Of: European journal of clinical investigation. Volume 48(2018)Supplement 2
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-11-07
• Subjects: bacteria -- CGD -- Crohn's -- gastroenteritis -- immunology -- infection -- inflammatory bowel disease; Pathology -- Periodicals; Medical research -- Periodicals; 616.075
• DOI: 10.1111/eci.12983
• Languages: English
• ISSNs: 0014-2972

Abstract

Abstract: Crohn's disease (CD) is caused by a trigger, almost certainly enteric infection by one of a multitude of organisms that allows faeces access to the tissues, at which stage the response of individuals predisposed to CD is abnormal. In CD the failure of acute inflammation results in the failure to recruit neutrophils to the inflammatory site, as a consequence of which the clearance of bacteria from the tissues is defective. The retained faecal products result in the characteristic chronic granulomatous inflammation and adaptive immune response. Impaired of digestion of bacteria and fungi by CGD neutrophils can result in a similar pathological and clinical picture. The neutrophils in CD are normal and their inadequate accumulation at sites of inflammation generally results from diminished secretion of proinflammatory cytokines by macrophages consequent upon disordered vesicle trafficking.