Inactivation of myostatin by photo-oxygenation using catalyst-functionalized peptides. Issue 62 (12th July 2019)

• Record Type: Journal Article
• Authors: Okamoto, Hideyuki; Taniguchi, Atsuhiko; Usami, Shoya; Taguchi, Akihiro; Takayama, Kentaro; Hayashi, Yoshio
• Is Part Of: Chemical communications. Volume 55:Issue 62(2019)
• Page Start: 9108
• Page End: 9111
• Publication Date: 2019-07-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc04368c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A myostatin-binding peptide which is functionalized by equipped with on/off switchable photo-oxygenation catalyst drastically inactivates myostatin, leading to a new therapeutic strategy for amyotrophic diseases. Abstract : Inhibition of myostatin is an attractive treatment for muscular dystrophy and other amyotrophic diseases. A myostatin-binding peptide was functionalized by equipped with an on/off switchable photo-oxygenation catalyst. This peptide induces a selective oxygenation of myostatin under near-infrared light, resulting in inactivation of myostatin. This peptide shows several orders of magnitude greater inhibitory effect than the original peptide.