Intramolecular electrochemical dehydrogenative N–N bond formation for the synthesis of 1, 2, 4-triazolo[1, 5-a]pyridines. Issue 15 (22nd July 2019)

• Record Type: Journal Article
• Authors: Li, Yong; Ye, Zenghui; Chen, Na; Chen, Zhenkun; Zhang, Fengzhi
• Is Part Of: Green chemistry. Volume 21:Issue 15(2019)
• Page Start: 4035
• Page End: 4039
• Publication Date: 2019-07-22
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc01895f
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A reagent-free electrochemical synthesis of valuable 1, 2, 4-triazolo[1, 5- a ]pyridines was developed with the N–N bond formation as the key step. Abstract : A metal- and oxidant-free intramolecular dehydrogenative N–N bond formation has been developed under mild and scalable electrolytic conditions. Various valuable 1, 2, 4-triazolo[1, 5- a ]pyridines were synthesized efficiently from the readily available N -(2-pyridyl)amidines. The reactions were conducted in a simple undivided cell under constant current conditions with n Bu4 NBr as both the redox mediator and the electrolyte. This protocol was applied to the efficient synthesis of key intermediates for anti-diabetic compounds.