Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide. Issue 62 (3rd July 2019)

• Record Type: Journal Article
• Authors: Inaba, Hiroshi; Yamamoto, Takahisa; Iwasaki, Takashi; Kabir, Arif Md. Rashedul; Kakugo, Akira; Sada, Kazuki; Matsuura, Kazunori
• Is Part Of: Chemical communications. Volume 55:Issue 62(2019)
• Page Start: 9072
• Page End: 9075
• Publication Date: 2019-07-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc04345d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Encapsulation of the GFP inside microtubules by using a Tau-derived peptide increased the stability, rigidity, and velocity of microtubules. Abstract : We constructed GFP-encapsulated microtubules (MTs) using a Tau-derived peptide which binds to their interior. The encapsulation of the GFP dramatically increased the rigidity of MTs, resulting in their enhanced velocity on a kinesin-coated substrate. Moreover, the GFP-encapsulated MTs were significantly more stable than normal MTs.