A palladium-catalyzed three-component cascade S-transfer reaction in ionic liquids. Issue 15 (8th July 2019)

• Record Type: Journal Article
• Authors: Li, Jianxiao; Wu, Yaodan; Hu, Miao; Li, Can; Li, Meng; He, Dandan; Jiang, Huanfeng
• Is Part Of: Green chemistry. Volume 21:Issue 15(2019)
• Page Start: 4084
• Page End: 4089
• Publication Date: 2019-07-08
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc01718f
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A palladium-catalyzed three component cascade S-transfer reaction for the assembly of functionalized 4-sulfenylisoxazoles in ionic liquids was described. Abstract : A palladium-catalyzed three component cascade S-transfer reaction of acetylinic oximes with aryl halides using readily available Na2 S2 O3 as an odorless sulfenylation reagent under aerobic conditions in ionic liquids was described. The present protocol features environmental friendliness, good functional group compatibility, odorless sulfenylation reagents, without any ligand or additive, and excellent atom and step economy. Remarkably, this cascade procedure will be bringing about further late-stage modification for the construction of structurally complex isoxazole scaffolds in synthetic and pharmaceutical chemistry.