Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice. Issue 5 (24th May 2019)

• Record Type: Journal Article
• Authors: Wan, Bing; Li, Yan; Sun, Shuangshuang; Yang, Yang; LV, Yanling; Wang, Li; Song, Meijuan; Chen, Meizi; Wu, Chengjiang; Pan, Hangcheng; Zhang, Xiuwei
• Is Part Of: Bioscience reports. Volume 39:Issue 5(2019)
• Publication Date: 2019-05-24
• Subjects: ganoderic acid A -- lipopolysaccharide -- lung injury -- nuclear factor kappaB -- rho-associated protein kinases; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20190301
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : The present study aimed to investigate the protective effects of ganoderic acid A (GAA) on lipopolysaccharide (LPS)-induced acute lung injury. In mouse model of LPS-induced acute lung injury, we found that GAA led to significantly lower lung wet-to-dry weight ratio and lung myeloperoxidase activity, and attenuated pathological damages. In addition, GAA increased superoxide dismutase activity, but decreased malondialdehyde content and proinflammatory cytokines levels in the bronchoalveolar lavage fluid. Mechanistically, GAA reduced the activation of Rho/ROCK/NF-κB pathway to inhibit LPS-induced inflammation. In conclusion, our study suggests that GAA attenuates acute lung injury in mouse model via the inhibition of Rho/ROCK/NF-κB pathway.