Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues. Issue 17 (1st September 2019)

• Record Type: Journal Article
• Authors: Cheng, Zhiming; Valença, Wagner O.; Dias, Gleiston G.; Scott, Jamie; Barth, Nicole D.; de Moliner, Fabio; Souza, Gabriela B.P.; Mellanby, Richard J.; Vendrell, Marc; da Silva Júnior, Eufrânio N.
• Is Part Of: Bioorganic & medicinal chemistry. Volume 27:Issue 17(2019)
• Page Start: 3938
• Page End: 3946
• Publication Date: 2019-09-01
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2019.07.017
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.