Betalain- and betacyanin-rich supplements' impacts on the PBMC SIRT1 and LOX1 genes expression and Sirtuin-1 protein levels in coronary artery disease patients: A pilot crossover clinical trial. (September 2019)

• Record Type: Journal Article
• Authors: Rahimi, Parisa; Mesbah-Namin, Seyed Alireza; Ostadrahimi, Alireza; Separham, Ahmad; Asghari Jafarabadi, Mohammad
• Is Part Of: Journal of functional foods. Volume 60(2019)
• Publication Date: 2019-09
• Subjects: Age-related diseases -- Atherosclerosis -- Opuntia stricta -- Prickly Pear -- Red Beetroot -- Sirtuin; ACS Acute Coronary Syndrome -- ACTB Beta-actin -- AU Arbitrary Unit -- CAD Coronary artery disease -- CI Confidence Interval -- DPPH 2, 2-diphenyl-1-picrylhydrazyl -- ERK Extracellular signal–Regulated Kinase -- ESR Erythrocyte Sedimentation Rate -- g gram -- HPLC High-performance liquid chromatography -- hs-CRP high sensitive C Reactive Protein -- ICAM-1 Intercellular Adhesion Molecule 1 -- IL Interleukin -- INF Interferon -- LOX1 Lectin-like Oxidized LDL Receptor 1 -- MCP-1 Monocyte Chemoattractant Protein 1 -- min minute -- NAD Nicotinamide adenine dinucleotide -- mg L−1 milligrams per liter -- N Number -- ng ml−1 nanograms per milliliter -- nm nanometer -- Oct-1 Octamer Transcription Factor 1 -- oxLDL Oxidized LDL -- P Probability value -- PBMC Peripheral Blood Mononuclear Cell -- ROS Reactive Oxygen Species -- SD Standard Deviation -- SEM Standard Error of the Mean -- SIRT1 Sirtuin1 -- TNF-α Tumor Necrosis Factor-α -- VCAM-1 Vascular Cell Adhesion Molecule 1; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2019.06.003
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Betalain-/betacyanin-rich supplements increased levels of Sirtuin-1. Betalains-/betacyanins-rich supplements decreased the expression levels of LOX1. Betalain and betacyanin-rich extracts lowered plasma levels of hs-CRP in CAD patients. Abstract: Activation of Sirtuin-1 (SIRT1) is a considered candidate for the prevention of cardiovascular diseases. SIRT1 as a longevity factor regulates human cell lifespan and influences aspects of age-dependent atherosclerosis. Betalains can significantly increase the lifespan of Caenorhabditis elegans . This effect may be agreeable with activation of SIRT1. Thus, this study investigates the effects of betalains on SIRT1 and Lectin-like Oxidized LDL Receptor 1 (LOX1) expression in coronary artery disease patients. Participants received three treatments (a betalains-rich supplement of red beetroot, a betacyanins-rich supplement of Opuntia stricta and a placebo; daily for two weeks) on three occasions which separated by washout periods. A notable elevation in SIRT1 levels and a considerable decrease in the expression levels of LOX1 and plasma concentration of high sensitive C Reactive Protein (hs-CRP) were observed after both supplementations. In conclusion, it appears that betalains could be considered as the new candidates in studies about age-related diseases.