Curcumin and its analogues protect from endoplasmic reticulum stress: Mechanisms and pathways. (August 2019)

• Record Type: Journal Article
• Authors: Shakeri, Abolfazl; Zirak, Mohammad Reza; Wallace Hayes, A.; Reiter, Russel; Karimi, Gholamreza
• Is Part Of: Pharmacological research. Volume 146(2019)
• Publication Date: 2019-08
• Subjects: ATF6 activating transcription factor 6 -- AIF apoptosis inducing factor -- BIP binding of immunoglobulin protein -- CDC25C cell division cycle 25C -- CDK1 cyclin dependent kinase 1 -- CHOP C/EBP homologous protein -- CLDM curcumin liquid droplet micromicellar formulation -- DDIT3 DNA damage inducible transcript 3 -- DAI diffuse axonal injury -- DM diabetes mellitus -- EEF2K eukaryotic elongation factor-2 kinase -- eIF2α eukaryotic initiation factor 2α -- ER endoplasmic reticulum -- Ero1 ER oxidoreductin 1 -- GRP78 glucose-regulated protein 78 -- HSPA5 heat shock 70 kDa protein 5 -- HUVECs human umbilical vein endothelial cells -- IRE1 inositol-requiring enzyme 1 -- JNK c-Jun N-terminal kinase -- MPZ myelin protein zero -- NASH nonalcoholic steatohepatitis -- Nrf2 nuclear factor erythroid 2–related factor 2 -- PDI protein disulfide isomerase -- PERK protein kinase-like ER kinase -- PLP1 proteolipid protein 1 -- PMD Pelizaeus-Merzbacher disease -- RCC renal cell carcinoma -- ROS reactive oxygen species -- STAT3 signal transducer and activator of transcription 3 -- SERCA sarcoplasmic or endoplasmic reticulum calcium -- TGF transforming growth factor -- Tr-J Trembler-J -- TXNIP thioredoxin-interacting protein -- UPR unfolded protein response -- XBP1 X-box binding protein 1 -- WHO World Health Organization -- ΔΨm mitochondrial membrane potential; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2019.104335
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: The endoplasmic reticulum (ER), a cellular organelle with multiple functions, plays an important role in several biological processes including protein folding, secretion, lipid biosynthesis, calcium homeostasis, and cellular stress. Accumulation of misfolded or unfolded proteins in the ER makes cells undergo a stress response known as the unfolded protein response (UPR). UPR is initially protective. However, prolonged and severe ER stress can lead to autophagy and/or the induction of apoptosis in stressed cell. Many studies have demonstrated that ER stress and the UPR are involved in different diseases such as neurodegenerative diseases, cancer, osteoporosis, diabetes, and inflammatory diseases. Curcumin, a natural polyphenol, has well documented evidence supporting its numerous biological properties including antioxidant, anti-inflammatory, immune-modulatory, anti-microbial, anti-ischemic, anti-angiogenesis, neuroprotective, hepatoprotective, nephroprotective, anti-atherogenic and anti-diabetic activities. In this review, the role of ER stress in several pathological condition and the potential protective effects of curcumin are discussed.