Stochastic single-molecule dynamics of synaptic membrane protein domains. (4th November 2016)

• Record Type: Journal Article
• Authors: Kahraman, Osman; Li, Yiwei; Haselwandter, Christoph A.
• Is Part Of: Europhysics letters. Volume 115:Number 6(2016:Sep.)
• Publication Date: 2016-11-04
• Subjects: 87.16.-b -- 87.19.lp -- 87.10.Mn; Physics -- Periodicals; Electronic journals; 530.05
• DOI: 10.1209/0295-5075/115/68006
• Languages: English
• ISSNs: 0295-5075

Abstract

Abstract: Motivated by single-molecule experiments on synaptic membrane protein domains, we use a stochastic lattice model to study protein reaction and diffusion processes in crowded membranes. We find that the stochastic reaction-diffusion dynamics of synaptic proteins provide a simple physical mechanism for collective fluctuations in synaptic domains, the molecular turnover observed at synaptic domains, key features of the single-molecule trajectories observed for synaptic proteins, and spatially inhomogeneous protein lifetimes at the cell membrane. Our results suggest that central aspects of the single-molecule and collective dynamics observed for membrane protein domains can be understood in terms of stochastic reaction-diffusion processes at the cell membrane.