Design of a novel magnetic platform for cell manipulation. (9th January 2018)

• Record Type: Journal Article
• Authors: Lucarini, Gioia; Iacovacci, Veronica; Gouveia, Pedro J; Ricotti, Leonardo; Menciassi, Arianna
• Is Part Of: Journal of micromechanics and microengineering. Volume 28:Number 2(2018:Feb.)
• Publication Date: 2018-01-09
• Subjects: lab-on-a- chip -- cell manipulation -- magnetic control -- magnetic platform -- microrobotics; Microelectromechanical systems -- Periodicals; Micromechanics -- Periodicals; 621.38105
• DOI: 10.1088/1361-6439/aaa269
• Languages: English
• ISSNs: 0960-1317

Abstract

Abstract: Cell manipulation tasks, especially in lab-on-a-chip applications for personalized medicine, could greatly benefit from mobile untethered microdevices able to wirelessly navigate in fluidic environments by means of magnetic fields. In this paper, the design, fabrication and testing of a magnetic platform enabling the controlled locomotion and immersion of microrobots placed at the air/liquid interface is proposed and exploited for cell manipulation. The proposed microrobot consists of a polymeric magnetic thin film that acts as cell transporter and a specific coating strategy, devised to enhance a safe cancer cell adhesion to the magnetic film. Experimental results demonstrated an overall cell viability and a fine control of magnetic microrobot locomotion. The proposed technologies are promising in view of future cell manipulation tasks for personalized medicine applications.