Effect of quercetin against mixture of four organophosphate pesticides induced nephrotoxicity in rats. (3rd March 2016)

• Record Type: Journal Article
• Authors: Li, Sifan; Cao, Can; Shi, Haidan; Yang, Shuang; Qi, Lei; Zhao, Xiujuan; Sun, Changhao
• Is Part Of: Xenobiotica. Volume 46:Number 3(2016:Mar.)
• Page Start: 225
• Page End: 233
• Publication Date: 2016-03-03
• Subjects: Acephate -- dichlorvos -- dimethoate -- nephrotoxicity -- NOAEL -- oxidative stress -- phorate -- quercetin; Metabolism -- Periodicals; Drugs -- Physiological effect -- Periodicals; Food additives -- Periodicals; Chemicals -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Pharmaceutical Preparations -- metabolism -- Periodicals; Metabolism -- Periodicals; 574.133
• DOI: 10.3109/00498254.2015.1070443
• Languages: English
• ISSNs: 0049-8254

Abstract

Abstract: 1. It has been demonstrated that the ingestion of foods containing quercetin protects against the toxicity of single pesticides. The aim of this study is to make a comprehensive elaboration about the protective effect of quercetin against multi-organophosphorous pesticides induced nephrotoxicity by measuring indices in rat kidney, urine and serum. Rats were divided into six groups ( n = 10/group): control, two different doses of quercetin, pesticide mixture (PM), and different doses of quercetin plus PM-treated groups. 2. The following parameters were significantly changed in PM-treated groups compared with the control ( p < 0.01). In kidney, malondialdehyde level raised; catalase, superoxide dismutase activities and glutathione levels were decreased. Comet assay of nephrocytes showed that the proportion of DNA in the tail and tail length increased. In urine, β2-microglobulin, retinol-conjugated protein levels and N -acetyl-β-d -glucosaminidase activity showed increasing response; meanwhile uric acid level was decreased. In serum, creatinine and urea nitrogen levels were increased. However, the anomaly changes of indexes mentioned above in PM-treated group were alleviated when simultaneously administrated with 50 mg/kg body weight/day quercetin ( p < 0.05). 3. From the present findings, it can be evaluated that quercetin may protect against adverse effects resulted from multi-organophosphorous pesticides with significant high levels of uptake in man provided.