Organocatalytic Asymmetric Domino Michael/Acyl Transfer Reaction Between α‐Nitroketones and in situ‐Generated ortho‐Quinone Methides: Route to 2‐(1‐Arylethyl)phenols. Issue 23 (30th October 2018)

• Record Type: Journal Article
• Authors: Gharui, Chandan; Behera, Debasmita; Pan, Subhas Chandra
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 23(2018)
• Page Start: 4502
• Page End: 4508
• Publication Date: 2018-10-30
• Subjects: o-Quinone methide -- α-nitroketone -- domino reaction -- 2-(1-arylethyl)phenol -- asymmetric -- organocatalysis; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201801015
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An organocatalytic asymmetric domino Michael/acyl transfer reaction between α ‐nitroketones and o ‐quinone methides is disclosed. o ‐Quinone methides are generated in situ from 2‐sulfonylmethylphenols in basic medium. With 10 mol% of bifunctional squaramide catalyst, high yields and excellent enantioselectivities are achieved for a variety of O‐acyl 2‐(1‐arylethyl)phenols under mild reaction condition. Abstract :