Temperature‐controlled Rhythmic Gene Expression in Endothermic Mammals: All Diurnal Rhythms are Equal, but Some are Circadian. (4th June 2018)

• Record Type: Journal Article
• Authors: Preußner, Marco; Heyd, Florian
• Is Part Of: BioEssays. Volume 40:Number 7(2018:Jul.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-06-04
• Subjects: alternative splicing -- body temperature -- circadian clock -- endothermic -- temperature‐controlled gene expression; Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.201700216
• Languages: English
• ISSNs: 0265-9247

Abstract

Abstract : The circadian clock is a cell autonomous oscillator that controls many aspects of physiology through generating rhythmic gene expression in a time of day dependent manner. In addition, in endothermic mammals body temperature cycles contribute to rhythmic gene expression. These body temperature‐controlled rhythms are hard to distinguish from classic circadian rhythms if analyzed in vivo in endothermic organisms. However, they do not fulfill all criteria of being circadian if analyzed in cell culture or in conditions where body temperature of an endothermic organism can be manipulated. Here we review and compare these characteristics, discuss the core clock independent mechanism of temperature‐controlled alternative splicing and highlight the requirement of double‐checking rhythms that appear circadian within an endothermic organism in a system that allows temperature manipulation. Abstract : Diurnal rhythms are characterized by daily recurring patterns. Here, the characteristics of self‐sustained circadian rhythms and body‐temperature entrained non‐circadian rhythms are compared, with a highlight on temperature‐controlled alternative splicing. Interactions of these two daily cycles and potential physiological roles of purely temperature‐controlled rhythms are discussed.