Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean. (October 2018)

• Record Type: Journal Article
• Authors: Nøstbakken, Ole Jakob; Duinker, Arne; Rasinger, Josef D.; Nilsen, Bente M.; Sanden, Monica; Frantzen, Sylvia; Hove, Helge T.; Lundebye, Anne-Katrine; Berntssen, Marc H.G.; Hannisdal, Rita; Madsen, Lise; Maage, Amund
• Is Part Of: Environment international. Volume 119(2018)
• Page Start: 544
• Page End: 557
• Publication Date: 2018-10
• Subjects: Brominated flame retardants -- Seafood -- Risk assessment -- Polybrominated diphenyl ethers -- Hexabromocyclododecane; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2018.04.044
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Brominated flame-retardants (BFRs) such as polybrominated diphenyl ethers (PBDE) and hexabromocyclododecane (HBCD) are considered hazardous to human health. Due to their persistence, they are still present in the environment and in biota and seafood is major contributor of BFRs to human exposure. Here, we used data from >9700 samples of wild and farmed fish, fish feed and fish feed ingredients collected from the North Atlantic between 2006 and 2016 aiming to investigate factors influencing the risk assessments of BFRs. Due to most representative number of analyses, PBDEs were the main focus of investigation. Mean ∑PBDE in fillet samples ranged from below quantification in Atlantic cod fillet to 2.0 μg kg −1 in Atlantic halibut. The main congener contributing to the ∑PBDE in all species was BDE 47. Factors affecting the level of BFR in seafood were multifaceted, and the levels were within species mainly determined by fish age, geographical origin and time of sampling. BDE 47, 99, 153 and HBCD were selected for margin of exposure (MOE) evaluation. When other sources of BFR than seafood were excluded, our risk assessment showed low risk at the current dietary intake of seafood. However, the dietary intake of BDE 99 may be of concern for toddlers when all sources are considered. The choice of fish species, dietary studies, choice of statistics, as well as exposure from other sources than seafood, were all factors that influenced the final MOE of BFRs. We propose the use of regression on order statistics as a tool for risk assessment, to illustrate means and spreads in large surveillance datasets to avoid the issue of measurements below the limit of quantification. A harmonized, updated evaluation of the risk associated with exposure to BFRs from diet, air and dust is warranted, where the fish species most commonly consumed also is taken into consideration. Highlights: Risk assessment of BDE 47, 99, 153 and HBCD in North East Atlantic seafood indicates low risk at current intake. BDE 99 could pose a risk at current dietary intake when all exposure sources of brominated flame-retardants are considered. The large variation in Levels of brominated flame retardants in different Seafood affects the outcome of risk assessments. Statistical interpretation of surveillance data affect the outcome of risk assessments.