Prevalence of GBS serotype III and identification of a ST 17-like genotype from neonates with invasive diseases in Guangzhou, China. (July 2018)

• Record Type: Journal Article
• Authors: Liu, Junyan; Xu, Ruirui; Zhong, Huamin; Zhong, Yukui; Xie, Yongqiang; Li, Lin; Li, Bing; Chen, Dingqiang; Xu, Zhenbo
• Is Part Of: Microbial pathogenesis. Volume 120(2018)
• Page Start: 213
• Page End: 218
• Publication Date: 2018-07
• Subjects: Serotype -- MLST -- Streptococcus agalactiae -- Neonate -- Invasive disease; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2018.05.002
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Objectives: The aim of this study is to understand the surveillance of Streptococcus agalactiae (GBS) serotype and genotype which help developing specific vaccine for GBS infection. Methods: The GBS serotype was determined by strep-B-Latex rapid agglutination method and multiplex PCR assay based on the differences among serotypes. Alleles and multilocus sequence types (MLST) were determined using the GBS MLST Website. Results: Four GBS serotypes (Ia, Ib, III, and V) were identified, with serotype III which was intimately associated with purulent meningitis and sepsis, as the dominance. In EOD cases, sepsis and pneumonia showed dominance, but purulent meningitis was dominant in LOD cases. Also, a new ST-17 like type which might be a clone derive from ST-17 and emerge among neonatal disease cases was identified. Conclusions: The prevalence of GBS serotype and genotype and their relation with GBS diseases guide the development of capsular polysaccharide vaccine. Highlights: Four GBS serotypes were identified, with type III intimately associated with purulent meningitis and sepsis, as dominance. In EOD cases, sepsis and pneumonia showed dominance, but purulent meningitis was dominant in LOD cases. A new ST-17 like type which might be a clone derive from ST-17 and emerge among neonatal disease cases was identified.