Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Issue 8 (November 2018)

• Record Type: Journal Article
• Authors: Winer, Lindsey; Macedo, Francisco I.; Alfawaz, Abdullah; Sommariva, Antonio; Cecchetto, Giovanni; Podda, Antonello; Neville, Holly L.; Möller, Mecker G.
• Is Part Of: Journal of pediatric hematology/oncology. Volume 40:Issue 8(2018)
• Publication Date: 2018-11
• Subjects: sarcoma -- abdominal sarcoma -- pelvic angiosarcoma -- pediatric sarcoma -- HIPEC; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001231
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : The management of pediatric abdominopelvic angiosarcoma remains unclear due to limited clinical experience. Herein, we presented the first 2 pediatric patients with abdominal angiosarcoma who were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) after neoadjuvant therapy. The first patient is alive with recurrent disease at 1-year follow-up and the second patient remains disease free after 1 year. CRS and HIPEC should be considered as a therapeutic option in the management of pediatric abdominal angiosarcomas. A multi-institutional international shared registry is needed to further evaluate the role of CRS and HIPEC in inducing remission of abdominopelvic angiosarcomas in the pediatric population.