Preparation of Fluconazole β-Cyclodextrin Complex Ocuserts: In Vitro and In Vivo Evaluation. (25th August 2011)

• Record Type: Journal Article
• Authors: Abdul Ahad, Hindustan; Sreeramulu, J.; Padmaja, B. Suma; Reddy, M. Narasimha; Prakash, P. Guru
• Other Names: de Julián-Ortiz J. V. Academic Editor.; Murata Y. Academic Editor.; Yener G. Academic Editor.
• Is Part Of: ISRN pharmaceutics. Volume 2011(2011)
• Publication Date: 2011-08-25
• Subjects: Pharmacy -- Periodicals; Pharmacological Phenomena; Pharmacology; Pharmacy; Electronic journals; Periodical; Periodicals; 615
• DOI: 10.5402/2011/237501
• Languages: English
• ISSNs: 2090-6145

Abstract

Abstract : The main purpose of the present study was to develop ocuserts of Fluconazoleβ -CD (beta-cyclodextrin) complex and to evaluate both in vitro and in vivo . Fluconazole was made complex withβ -CD, and the release rate was controlled by HPMC K4 M and ethyl cellulose polymers using dibutyl Phthalate as permeability enhancer. Drug-polymer interactions were studied by Fourier transform infrared spectroscopic studies. The formulated ocuserts were tested for physicochemical parameters of in vitro release and in vivo permeation in rabbits. The optimized formulations (F-5 and F-8) were subjected to stability studies. The formulated ocuserts were found to have good physical characters, thickness, diameter, uniformity in weight, folding endurance, less moisture absorption, and controlled release of drug both in vitro and in vivo . The optimized formulations retained their characteristics even after stability studies. The study clearly showed that this technique was an effective way of formulating ocuserts for retaining the drug concentration at the intended site of action for a sufficient period of time and to elicit the desired pharmacological response.