Anaesthesia and the Acute Phase Protein Response in Children Undergoing Circumcision. Issue 5 (24th October 2005)

• Record Type: Journal Article
• Authors: Buyukkocak Buyukkocak, Unase Unase; Caglayan Caglayan, Fatma Fatma; Caglayan Caglayan, Osman Osman; Basar Basar, Murat Murat; Cakmak Cakmak, Murat Murat; Batislam Batislam, Ertan Ertan; Ulusoy Ulusoy, Sevgi Sevgi
• Is Part Of: Mediators of inflammation. Volume 2005:Issue 5(2005)
• Page Start: 312
• Page End: 315
• Publication Date: 2005-10-24
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/MI.2005.312
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : Concentrations of acute phase proteins (CRP: C-reactive protein, albumin) change during surgery. We investigated the acute phase response to circumcision and the effects of anaesthesia on this response. The children were divided into four groups; group 1 (intratracheal general anaesthesia, n = 40 ), group 2 (general anaesthesia with mask, n = 20 ), group 3 (ketamine, n = 20 ), group 4 (local anaesthesia, n = 35 ). Blood samples were obtained, 24 hours before circumcision, after premedication, and 24 hours after circumcision. CRP and albumin before circumcision were comparable for all groups. There was no increase in CRP, and albumin remained steady throughout the study. No difference was observed among the groups, and related to anaesthesia. No responsiveness may be explained with the size of injured tissue or anatomical and histological type of preputium.