Age-Related Modifications in Circulating IL-15 Levels in Humans. Issue 4 (2005)

• Record Type: Journal Article
• Authors: Gangemi Gangemi, Sebastiano Sebastiano; Basile Basile, Giorgio Giorgio; Monti Monti, Daniela Daniela; Merendino Merendino, Rosaria Alba Rosaria Alba; Pasquale Pasquale, Giuseppe Di Giuseppe Di; Bisignano Bisignano, Ursula Ursula; Nicita-Mauro Nicita-Mauro, Vittorio Vittorio; Franceschi Franceschi, Claudio Claudio
• Is Part Of: Mediators of inflammation. Volume 2005:Issue 4(2005)
• Page Start: 245
• Page End: 247
• Publication Date: 2005
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/MI.2005.245
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : Aging is associated to a progressive establishing of a chronic inflammatory state linked to a continuous long exposure to antigens. Since IL-15 stimulates the proliferation of memory T cells and the immunosenescence is characterized by accumulation of memory T cells and exhaustion of naive T cells, we analyzed IL-15 levels in sera from 30 ultralongeval subjects with respect to those from young and old adults. IL-15 levels were assayed by immunoenzymatic methods. Ultralongeval subjects displayed significantly higher IL-15 levels with respect to both young and old controls. No statistical difference was found between old and young controls. These findings may explain, at least in part, the characteristic increase of memory cells in immunosenescence and the capacity of the immune system of centenarians to defend itself from infections through immune-inflammatory responses.