Diffuse Involvement of Aorta in Patient with Familial Hyperlipidemia. (3rd April 2011)

• Record Type: Journal Article
• Authors: Can, Mehmet Mustafa; Tanboga, Ibrahim Halil; Akgun, Taylan
• Other Names: Baines C. Academic Editor.; Cademartiri F. Academic Editor.; Glogar D. H. Academic Editor.
• Is Part Of: ISRN cardiology. Volume 2011(2011)
• Publication Date: 2011-04-03
• Subjects: Cardiovascular system -- Diseases -- Periodicals; Cardiovascular Diseases; Cardiovascular system -- Diseases; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 616.1
• DOI: 10.5402/2011/804767
• Languages: English
• ISSNs: 2090-5580

Abstract

Abstract : Familial hyperlipidemia (FH) is an inherited metabolic disorder caused by low-density lipoprotein (LDL) receptor abnormality. The delayed clearance of serum LDL results in severe hypercholesterolemia, which leads to the accumulation of LDL-derived cholesterol in skin, tendons, and arterial walls.In homozygous form of the disease, severely atheromatous involvement of the aorta extending to the coronary ostia is almost always present, and particular surgical strategy is required to prevent atheroembolic events.