C-kit and bcl-2 Are Not Useful Markers in Differentiating Adenoid Cystic Carcinoma from Polymorphous Low-Grade Adenocarcinoma. (15th July 2011)

• Record Type: Journal Article
• Authors: Meer, Shabnum; Singh, Sunita; Altini, Mario
• Other Names: Navarro A. Academic Editor.; Schildhaus H.-U. Academic Editor.
• Is Part Of: ISRN pathology. Volume 2011(2011)
• Publication Date: 2011-07-15
• Subjects: Pathology -- Periodicals; Pathology; Pathology; Electronic journals; Periodical; Fulltext; Internet Resources; Periodicals; Periodicals; 616.07
• DOI: 10.5402/2011/415614
• Languages: English
• ISSNs: 2090-570X

Abstract

Abstract : Aims . To evaluate the immunohistochemical expression of bcl-2 and c-kit proteins in the salivary gland tumors, adenoid cystic carcinoma, and polymorphous low-grade adenocarcinoma with a view to tumor differentiation. Methods . Immunohistochemical studies were performed on 29 adenoid cystic carcinoma and 23 polymorphous low-grade adenocarcinoma archival cases with bcl-2 and c-kit antibodies using standard procedures, and the data were statistically analyzed. Results . The difference in bcl-2 expression in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma was not statistically significant. Whilst the difference in c-kit expression was statistically significant (P = 0.01 ), the difference proved small so as to be of no practical or diagnostic importance. Moderate to strong immunostaining was noted in adenoid cystic carcinoma with c-kit, the pattern and intensity varying within different histological subtypes, being greater the more aggressive the tumor subtype. Conclusions . Bcl-2 and c-kit are not useful as immunohistochemical markers in differentiating adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma.