Predisposing Factors for Deep Venous Thrombosis in Children and Adolescents with Nephrotic Syndrome. (17th November 2011)

• Record Type: Journal Article
• Authors: Candelaria, Gabriela de Toledo Passos; Belangero, Vera Maria Santoro
• Other Names: Jayachandran M. Academic Editor.
• Is Part Of: ISRN vascular medicine. Volume 2011(2011)
• Publication Date: 2011-11-17
• Subjects: Cardiology -- Periodicals; Cardiology; Vascular Diseases -- Periodicals; Vascular Surgical Procedures -- Periodicals; Periodicals; Electronic journals; 616.13
• DOI: 10.5402/2011/827483
• Languages: English
• ISSNs: 2090-5823

Abstract

Abstract : Nephrotic syndrome (NS) is a state of hypercoagulability. In this paper, we sought to determine risk factors for the occurrence of deep vein thrombosis (DVT) in children with NS. The "with DVT" group included patients with decompensated NS and diagnosed with DVT. The "without DVT" group included the same patients, six to eighteen months prior to the episode of DVT, with decompensated NS but without DVT. Different prediction variables were analyzed. The odds ratio for the occurrence of DVT in patients with triglyceride levels ≥300 mg/dL was 3.14 (95% CI 1.14 to 8.64). For hematocrit levels ≥43% and for the presence of infection or a severe systemic event, the odds ratio was 4.37 (95% CI 1.23 to 15.53). The presence of significant risk factors for the occurrence of DVT in children with NS may serve as a warning for the occurrence of venous thrombosis.