Effects of a topical lotion containing aminophylline, caffeine, yohimbe, l‐carnitine, and gotu kola on thigh circumference, skinfold thickness, and fat mass in sedentary females. (19th November 2018)

• Record Type: Journal Article
• Authors: Escalante, Guillermo; Bryan, Patrick; Rodriguez, Juan
• Is Part Of: Journal of cosmetic dermatology. Volume 18:Number 4(2019:Aug.)
• Page Start: 1037
• Page End: 1043
• Publication Date: 2018-11-19
• Subjects: aminophylline -- caffeine -- fat reduction -- gotu kola -- l‐carnitine -- yohimbe; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.12801
• Languages: English
• ISSNs: 1473-2130

Abstract

Abstract: Background and objective: Topical aminophylline, caffeine, yohimbe, l ‐carnitine, and gotu kola ( Centella asiatica ) may aid in reducing body fat. Lipoxyderm™ contains these ingredients and was used to test if fat loss of the thigh, in conjunction with a low intensity exercise program and restricted calorie intake, was enhanced via the topical application of this lotion. Methods: This was a double‐blind, placebo‐controlled, within‐group study that investigated the effects of Lipoxyderm™ on thigh fat mass, circumference, and skinfold thickness. Seven participants underwent pre/post‐exercise testing for weight, bilateral thigh circumference/skinfold thickness, and body composition/thigh fat mass assessment via dual‐energy X‐ray absorptiometry. Participants followed a hypocaloric diet, walked 150 minutes/wk, and were randomly assigned to apply a placebo to one leg and Lipoxyderm™ to their other leg for 28 days. Separate two‐way mixed factorial repeated measures ANOVAs were used to compare the effects of Lipoxyderm™ to the placebo on thigh circumference, skinfold thickness, and fat mass. Results: A significant time x group interaction was found for thigh circumference ( F 1, 6 = 18.2, P = 0.005), skinfold thickness ( F 1, 6 = 14.6, P = 0.009), and fat mass ( F 1, 6 = 37.1, P = 0.001). Conclusions: A twice‐daily topical application of Lipoxyderm™ for 28 days compared to a placebo combined with a walking program and a restricted caloric intake is more effective at reducing thigh circumference (1.2 vs 0.8 cm), thigh skinfold thickness (3.7 vs 2.0 mm), and thigh fat mass (100.0 g vs 57.3 g).