Genotyping microhaplotype markers through massively parallel sequencing. (December 2017)

• Record Type: Journal Article
• Authors: Zhu, Jing; Chen, Peng; Qu, Shengqiu; Wang, Hui; Chen, Dan; Liang, Weibo; Zhang, Lin
• Is Part Of: Forensic science international. Volume 6(2017)
• Page Start: e314
• Page End: e316
• Publication Date: 2017-12
• Subjects: Microhaplotype -- Mixture -- The ratio of two contributors' depth of coverage (DOCR); Forensic genetics -- Periodicals; Forensic Genetics -- Periodicals; Electronic journals; 614.1
• DOI: 10.1016/j.fsigss.2017.09.128
• Languages: English
• ISSNs: 1875-1768

Abstract

Abstract: Mixture interpretation is challenging at present. Short tandem repeats (STR) and single nucleotide polymorphism (SNP) are still in mainstream in forensic genetics, but both of them are not good enough for mixture interpretation. Microhaplotype is a potentially polymorphic genetic marker. In this study, DNA mixtures were simulated at different mixing ratio, and microhaplotype markers were used to analyzing the mixtures through massively parallel sequencing (MPS).