How does the chemical potential of the substrate drive a uniporter?. (11th February 2016)

• Record Type: Journal Article
• Authors: Zhang, Xuejun C.; Han, Lei
• Is Part Of: Protein science. Volume 25:Number 4(2016:Apr.)
• Page Start: 933
• Page End: 937
• Publication Date: 2016-02-11
• Subjects: uniporters -- differential binding energy -- elastic conformational energy -- transition‐state energy barrier -- rate‐limiting step -- kinetic asymmetry; Proteins -- Periodicals; 572.6
• DOI: 10.1002/pro.2885
• Languages: English
• ISSNs: 0961-8368

Abstract

Abstract: Uniporters are a large class of transporters mediating facilitated diffusion of substrates along the direction of the substrate concentration gradient. Recently, structures of several important uniporters have been reported; however, the precise mechanisms of uniporter function remain subject of debate. Here, we present a series of general thermodynamic descriptions of uniporters, aimed at understanding the structure‐function relationship of uniporters, and in particular to reconcile biochemical phenomena of uniporters with our previously proposed thermodynamic model of general transporters.