Microfluidic Based Optical Microscopes on Chip. Issue 10 (13th September 2018)

• Record Type: Journal Article
• Authors: Paiè, Petra; Martínez Vázquez, Rebeca; Osellame, Roberto; Bragheri, Francesca; Bassi, Andrea
• Is Part Of: Cytometry. Volume 93:Issue 10(2018)
• Page Start: 987
• Page End: 996
• Publication Date: 2018-09-13
• Subjects: optofluidics -- optical microscopy -- lab on chip -- brightfield -- fluorescence; Flow cytometry -- Periodicals; Imaging systems in biology -- Periodicals; Imaging systems in medicine -- Periodicals; Diagnostic imaging -- Periodicals; 571.605
• DOI: 10.1002/cyto.a.23589
• Languages: English
• ISSNs: 1552-4922

Abstract

Abstract: Last decade's advancements in optofluidics allowed obtaining an ever increasing integration of different functionalities in lab on chip devices to culture, analyze, and manipulate single cells and entire biological specimens. Despite the importance of optical imaging for biological sample monitoring in microfluidics, imaging is traditionally achieved by placing microfluidics channels in standard bench‐top optical microscopes. Recently, the development of either integrated optical elements or lensless imaging methods allowed optical imaging techniques to be implemented in lab on chip systems, thus increasing their automation, compactness, and portability. In this review, we discuss known solutions to implement microscopes on chip that exploit different optical methods such as bright‐field, phase contrast, holographic, and fluorescence microscopy.