Elevated nitric oxide levels associated with hepatic cell apoptosis during liver injury. Issue 2 (5th September 2016)

• Record Type: Journal Article
• Authors: Liu, Hui; Li, Qian; Wang, Ying; Hong, Huimin; Chen, Mengting; Wang, Yingyi; Hong, Fenfang; Yang, Shulong
• Is Part Of: Hepatology research. Volume 47:Issue 2(2017)
• Page Start: 178
• Page End: 185
• Publication Date: 2016-09-05
• Subjects: apoptosis -- hepatic injury -- liver cell -- nitric oxide; Liver -- Diseases -- Periodicals; Liver Diseases -- Periodicals; Foie -- Maladies -- Périodiques; 616.362
• DOI: 10.1111/hepr.12783
• Languages: English
• ISSNs: 1386-6346

Abstract

Abstract : Hepatic injury is a major event in liver surgery such as liver transplantation and it always leads to hepatic cell apoptosis. Nitric oxide (NO) is a key signaling regulation molecule. Many researchers have shown that increased NO level can influence liver cell apoptosis by promoting or inhibiting the relative signaling pathways that are involved in the caspase family, Bax/Bcl‐2, mitochondria, oxidative stress, death receptors, and mitogen‐activated protein kinases. Elucidating the relationships between NO and hepatic cell apoptosis is necessary for ameliorating prognosis of liver surgery. This article reviews the newest research progress in the relationships between higher NO levels and hepatic cell apoptosis in liver injury.