Domino Oxidative Cyclization for the One‐Pot Synthesis of Pyrrolo[1,  2‐a]quinoxaline Derivatives. Issue 34 (11th September 2018)

• Record Type: Journal Article
• Authors: Reddy, Lonka Madhava; Reddy, Vulupala Veerabadra; Putta, Chandra Shekar; Satteyyanaidu, Vallabhareddy; Reddy, Chepyala Krishna; Subba Reddy, Basi V.
• Is Part Of: ChemistrySelect. Volume 3:Issue 34(2018)
• Page Start: 9881
• Page End: 9884
• Publication Date: 2018-09-11
• Subjects: Aryl acetylenes -- Molecular iodine -- Oxidative cyclization -- Pyrrolo[1, 2-a] quinoxalines -- Styrenes; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201800960
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: An oxidative cyclization of 1‐(2‐aminophenyl)pyrrole with styrenes has been developed for the synthesis of pyrrolo[1, 2‐ a ]quinoxaline derivatives using I2 /2‐iodoxybenzoic acid (IBX) in DMSO as an effective oxidant. I2 is found to catalyze effectively the oxidative cyclization of phenylacetylene and ethyl benzoylacetate with 1‐(2‐aminophenyl)pyrrole even in the absence of IBX to generate pyrrolo[1, 2‐ a ]quinoxaline derivatives under metal‐free conditions. Abstract : An oxidative cyclization of 1‐(2‐aminophenyl)pyrrole with styrenes has been developed for the synthesis of pyrrolo[1, 2‐ a ]quinoxaline derivatives using I2 /2‐iodoxybenzoic acid (IBX) in DMSO as an effective oxidant. I2 is found to catalyze effectively the oxidative cyclization of phenylacetylene and ethyl benzoylacetate with 1‐(2‐aminophenyl)pyrrole even in the absence of IBX to generate pyrrolo[1, 2‐ a ]quinoxaline derivatives under metal‐free conditions. This method works with a wide range of substrates.