Multicomponent Methanolysis Reaction for the Synthesis Pyrrole and Pyrolizine Derivatives via Intermolecular (3 + 2) Cycloaddition. Issue 34 (4th December 2017)

• Record Type: Journal Article
• Authors: Shirsat, Prashishkumar K.; Khomane, Navnath B.; Mali, Prakash R.; Maddi, Raghavender Reddy; Nanubolu, Jagadeesh Babu; Meshram, Harshadas M.
• Is Part Of: ChemistrySelect. Volume 2:Issue 34(2017)
• Page Start: 11218
• Page End: 11222
• Publication Date: 2017-12-04
• Subjects: Dienophile -- Heterocycles -- Methanol -- N-ylide -- Synthetic methodologies; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201702729
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A transition‐metal‐free and a mild multicomponent methanolysis protocol has been developed to access pyrrole and pyrolizine derivatives from readily available substrates ninhydrin, alkyne and amine. The reaction works well with both primary and secondary amines with a simple variation in temperature. The reaction is proposed to go through a (3+2) cycloaddition reaction via azomethine ylide intermediate. Abstract : One pot multicomponent reaction for the efficient and convenient synthesis of heterocyclic pyrrole and pyrolizine derivatives by using easily available starting material and simple reaction condition. Further, this methanolysis reaction is go through a (3+2) cycloaddition reaction via formation of azomethine ylide intermediate.