Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males. Issue 7 (29th May 2019) - Zhao, Wenhui
Abstract: Background: Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent malignant neoplasms of the upper respiratory tract. Studies have confirmed that an unstable chromosome constitution promotes the progress of laryngeal tumorigenesis, and ACYP2 has been confirmed as a telomere length‐related gene. However, to date, the association between ACYP2 polymorphisms and LSCC susceptibility has not been investigated. Methods: We performed this study to explore the effect of 11 single‐nucleotide polymorphisms (SNPs) in ACYP2 on LSCC susceptibility in Chinese Han males. Unconditional logistic regression analysis adjusted for age was used to calculate the odds ratios and 95% confidence intervals. Results: Based on allele and genotype models, our results showed that rs1682111 variant was significantly associated with a decreased LSCC susceptibility ( p < 0.05). On the contrary, polymorphisms of rs10439478, rs11125529, rs12615793, rs843711, rs11896604, and rs17045754 were significantly associated with an increased LSCC risk ( p < 0.05). The results of haplotype analysis indicated that haplotypes "TTCTCG" and "TTCTAA" in block 1 and "TG" in block 2 showed a risk factor for the development of LCSS ( p = 0.009, p < 0.001, and p = 0.001, respectively). The results of Genotype‐Tissue Expression analysis indicate that these significant SNPs were known to be associated with ACYP2 expression. Conclusion: Our data demonstrated that ACYP2 polymorphisms may exert effects on LSCC susceptibility in Chinese Han males. Abstract : In this study, we aimed to investigate the association between ACYP2 polymorphisms and laryngeal cancer risk in Chinese Han males. The results showed that rs1682111 was associated with a decreased risk of laryngeal squamous cell carcinoma (LSCC), while rs10439478, rs11125529, rs12615793, rs843711, rs11896604, and rs17045754 play a harmful role in the development of LSCC. Furthermore, the results of Genotype‐Tissue Expression analysis indicate that these significant single‐nucleotide polymorphisms were known to be associated with ACYP2 expression. Our findings indicate that ACYP2 may play a crucial role in the process of laryngeal canceration.